ASIA unversity:Item 310904400/108323
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 94286/110023 (86%)
造访人次 : 21710402      在线人数 : 316
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/108323


    题名: Mesoporous surface topography promotes bone cell differentiation on low elastic modulus Ti-25Nb-25Zr alloys for bone implant applications
    作者: Jean-Heng Ch;Jean-Heng Chang;Jeng-Fen Liu;Ying-Sui Sun;Chia-Ping W;Chia-Ping Wu;黃何雄;Her-Hsiung Huang;Yong Han
    贡献者: 生物資訊與醫學工程學系
    日期: 2017-06
    上传时间: 2017-11-03 06:09:26 (UTC+0)
    摘要: Reducing the elastic modulus of metallic bone implants can decrease the stress shielding effect between the implants and bone tissue. Ti alloys containing elements without biological side effects have shown considerable potential as alternatives of biomedical Ti–Al–V alloys in bone implant applications. Ti alloys with porous surface topography have been shown to enhance cell response. This paper developed a rapid electrochemical anodization process for the creation of a low elastic modulus Ti–25Nb–25Zr (Ti25Nb25Zr) alloy with mesoporous topography for bone implant applications. We also investigated the effects of the mesoporous surface topography on bone cell differentiation. The surface mesotopography presented a pore size of <20 nm. Compared to untreated Ti25Nb25Zr alloys, the proposed electrochemical anodization treatment increased the formation of focal adhesion complex protein (vinculin) and the subsequent integrin-mediated pathway (i.e., the expression of focal adhesion kinase). This in-turn enhanced the expression of various osteogenic markers, including the gene and protein expression of osteopontin, bone sialoprotein, and type I collagen, from human bone marrow mesenchymal stem cells. An increase in osteogenic markers is expected to promote osseointegration on Ti25Nb25Zr alloys used in bone implant applications. To the best of our knowledge, this is the first study to enhance osteogenic gene and protein expression by producing a low elastic modulus Ti25Nb25Zr alloy with a mesoporous surface structure.
    關聯: JOURNAL OF ALLOYS AND COMPOUNDS
    显示于类别:[生物資訊與醫學工程學系 ] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    index.html0KbHTML355检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈