The Contribution of MMP-7 Promoter Polymorphisms in Renal Cell Carcinoma

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题名:	The Contribution of MMP-7 Promoter Polymorphisms in Renal Cell Carcinoma
作者:	Tsai, 廖丞晞；Cheng-Hsi Liao；Wen-Shin Cha；Wen-Shin Chang；Pei-Shin Hu；Pei-Shin Hu；Hsi-Chun Wu；Hsi-Chun Wu；Shih-Wei Hsu；Shih-Wei Hsu；Yen-Fang Liu；Yen-Fang Liu；Shih-Ping Li；Shih-Ping Liu；Huey-Shan Hu；Huey-Shan Hung；包大?；Da-Tian Bau；Chia-Wen Tsa；Chia-Wen
贡献者:	生物資訊與醫學工程學系
日期:	2017-07
上传时间:	2017-11-03 06:05:54 (UTC+0)
摘要:	Background/Aim: Mounting evidence has suggested that polymorphisms in the promoters of matrix metalloproteinase (MMP) genes are associated with the risk of many types of cancer, but no study has ever explored these polymorphisms as biomarkers for renal cell cancer (RCC). Recently, it was suggested that serum MMP-7 levels have both diagnostic and prognostic potential for RCC. In this study, we focused on the contribution of two functional polymorphisms in the promoter region of MMP-7 (A-181G and C-153T) to RCC. Materials and Methods: These two polymorphisms were genotyped in 92 patients with RCC and 580 controls by PRC-RFLP analysis. Results: The results showed that there is no significant association of the RCC risk with the MMP-7 A-181G genotype, even after adjusted for the possible confounding factors. The MMP-7 C-153T polymorphism was not identified among the subjects investigated. Conclusion: Our findings suggest that the two MMP-7 polymorphisms A-181G and C-153T do not play a major role in determining personal susceptibility to RCC in Taiwan.
關聯:	IN VIVO
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

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