Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/108224

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题名:	Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development
作者:	Bin Wang;Ying-Erh Cho;Ying-Erh Chou;Ming-Yu Lien;Chen-Ming Su;Shun-Fa Yang;湯智昕;Chih-Hsin Tang
贡献者:	生物科技學系
日期:	2017-06
上传时间:	2017-10-30 02:44:34 (UTC+0)
摘要:	Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the third most common cause of cancer mortality. In Taiwan, HCC is the second leading cause of cancer death. CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. Polymorphisms in chemokine genes help to determine host-pathogen interactions that influence chemokine levels. We investigated the effects of CCL4 gene polymorphisms on the risk of hepatocellular carcinoma (HCC) disease progression in a cohort of Taiwanese patients. We recruited total of 1,546 participants in current study, including 1,200 healthy control and 346 patients with HCC. Three single-nucleotide polymorphisms (SNPs) of the CCL4 gene were examined by a real-time PCR. We found that the A/G homozygotes of CCL4 rs10491121 polymorphism reduced the risks for HCC. On the other hand, AG and GA haplotypes of 2 CCL4 SNPs (rs1049112 and rs171915) also reduced the risks for HCC by 0.025 and 0.515 fold, respectively. The present report is the first time to examine the risk factors associated with CCL4 SNPs in HCC progression in Taiwan.
關聯:	International Journal of Medical Sciences
显示于类别:	[生物科技學系] 期刊論文

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