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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108194


    Title: Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer
    Authors: Wei-Lan Yeh;蔡政芳;Cheng-Fang Tsai
    Contributors: 生物科技學系
    Date: 2017-07
    Issue Date: 2017-10-30 02:43:31 (UTC+0)
    Abstract: Background: Mesenchymal stem cells in tumor microenvironment can influence therapeutic responses in various
    types of cancers. For triple negative breast cancer, chemotherapy remains the mainstay of standard treatment. Our
    aim was to investigate the correlation between human adipose-derived stem cells (hAdSCs) and chemoresistance
    in triple negative breast cancer.
    Method: Conditioned medium was collected from hAdSCs, which was isolated from breast cancer patients
    who had had breast mastectomy. The expression of selected CD markers was evaluated by flow cytometry to
    characterize hAdSCs. By array analyses of the secreted cytokines and chemokines of hAdSCs, we identified
    CXCL1 that mediated doxorubicin resistance and the expression of ATP-binding cassette transporters ABCG2 in
    TNBC. By microRNA microarray, the association between hAdSC-mediated doxorubicin resistance in TNBC was
    also revealed.
    Results: Conditioned medium collected from hAdSCs elicited doxorubicin resistance and enhanced the
    expression of ABCG2, which is a transporter responsible for the efflux of doxorubicin. CXCL1 secreted by
    hAdSCs downregulated miR-106a expression in triple negative breast cancer, and resulted in ABCG2
    upregulation and doxorubicin resistance.
    Conclusions: Our findings suggest that CXCL1 secreted by hAdSCs elicits doxorubicin resistance through
    miR-106a-mediated ABCG2 upregulation in triple negative breast cancer. These findings provide a better
    understanding of the importance of adipose-derived stem cells in breast cancer microenvironment regarding
    to the development of chemoresistance and reveal the potential of discovering novel therapeutic strategies to
    overcome drug resistance in TNBC.
    Keywords: Adipose-derived stem cells, ABCG2, Drug resistance, Triple negative breast cancer
    Relation: Stem Cell Research & Therapy
    Appears in Collections:[Department of Biotechnology] Journal Article

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