Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/108176

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题名:	Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum
作者:	Pei-Yu Chao;Tsay-I Chian;Tsay-I Chiang;Chang Chang;Fang-Ling Ts;Fang-Ling Tsai;Hsueh-Hui Le;Hsueh-Hui Lee;Kuanghui Hsi;Kuanghui Hsieh;Yung-Wei Chi;Yung-Wei Chiu;Te-Jen Lai;Jer-Yuh Liu;Li-Sung Hsu;施養佳;Yang-Chia Shih
贡献者:	生物科技學系
日期:	2017-07
上传时间:	2017-10-30 02:42:53 (UTC+0)
摘要:	Objectives: Menopausal transition in women initiates with declining estrogen levels and is followed by significant changes in their physiological characteristics. These changes often lead to medical conditions, such as obesity, which is correlated with chronic low-grade/subclinical inflammation. Ocimum gratissimum L. is a food spice or traditional herb in many countries; the plant is rich in antioxidants, which possess anti-inflammation activities and multitude of other therapeutic functions. Methods: In this study, we evaluated effects of O. gratissimum extract (OGE) in preventing obesity by using ovariectomized (OVX) animal models to mimic menopausal women. Methods: OVX rats showed increase in body weight and in adipocyte size in perigonadal adipose tissue (p <0.05) and decrease in uterus weight. By contrast, OGE (0.2 mg/ml) significantly reduced body weight gain and adipocyte in OVX rats and showed insignificant changes in uterus weight. Further investigation indicated that OGE exerted no influence on levels of dorsal fat, serum total cholesterol, and serum triacylglycerol and on serum biochemical factors, calcium, phosphorus, and glucose. Conclusion: These findings suggested that OGE dietary supplements may be useful in controlling body weight of menopausal women.
關聯:	International Journal of Medical Sciences
显示于类别:	[生物科技學系] 期刊論文

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