ASIA unversity:Item 310904400/108095
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    题名: Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats
    作者: Padma, Lohanathan B；Lohanathan Bharathi Priya；Rathinasamy；Rathinasamy Baskaran；Pitchai Elan；Pitchai Elangovan；Velumani Dhi；Velumani Dhivya；黃志揚；Chih-yang Huang；Viswanadha V；Viswanadha Vijaya
    贡献者: 生物科技學系
    日期: 2017
    上传时间: 2017-10-30 02:36:34 (UTC+0)
    摘要: Persistence of cadmium (Cd) in the environment causes serious ecological problems. Tinospora cordifolia is a medicinal herb used in Ayurveda for treating various metabolic disorders and toxic conditions. The present study investigates the protective effect of T. cordifolia stem methanolic extract (TCME) on a heavy metal, Cd-induced cardiotoxicity in male Wistar rats. Male albino Wistar rats were divided into four groups (n = 6). The animals after treatment for 28 days with Cd and TCME were analysed for biochemical and histological changes in the serum and heart tissues. Cd induced lipid peroxidation and protein carbonylation was significantly reduced by TCME. TCME also reduced the histological alterations induced by Cd treatment in the heart tissues with diminished loss of myocardial fibers. Administration of TCME effectively prevented the altered levels of serum marker enzymes (creatine kinase and lactate dehydrogenase), antioxidants, such as superoxide dismutase, catalase, glutathione, glutathione peroxidase and glutathione-S-transferase, and glycoproteins contents such as hexose, hexoseamine, fucose, and sialic acid by Cd intoxication. TCME also offered protection against the change in levels of Na+K+ATPase, Mg2+ATPase and Ca2+ATPase activities against Cd toxicity. The study suggests TCME as a potent cardioprotective agent against Cd induced toxicity.

    Keywords
    CadmiumTinospora cordifoliaOxidative stressHeartAntioxidant enzymes
    關聯: BIOMEDICINE & PHARMACOTHERAPY
    显示于类别:[生物科技學系] 期刊論文

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