Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder

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Title:	Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder
Authors:	Lee, 王姿云；Tzu-Yun Wang；李聖玉；Sheng-Yu Lee；陳秀蘭；Shiou-Lan Chen；張芸瑄；Yun-Hsuan Chang；王亮人；Liang-Jen Wang；陳柏熹；Po See Chen；陳世恆；Shih-Heng Chen；朱俊憲；Chun-Hsien Chu；李佳玲；Chia-Ling Li；鍾宜倫；Yi-Lun Chung；謝采芯；Tsai-Hsin Hsieh；李怡慧；I Hui
Contributors:	心理學系
Date:	2017
Issue Date:	2017-10-27 08:45:19 (UTC+0)
Abstract:	Patients with subthreshold hypomania (SBP; subthreshold bipolar disorder) were indistinguishable from those with bipolar disorder (BP)-II on clinical bipolar validators, but their analyses lacked biological and pharmacological treatment data. Because inflammation and neuroprogression underlies BP, we hypothesized that cytokines and brain-derived neurotrophic factor (BDNF) are biomarkers for BP. We enrolled 41 drug-naïve patients with SBP and 48 with BP-II undergoing 12 weeks of pharmacological treatment (valproic acid, fluoxetine, risperidone, lorazepam). The Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) were used to evaluate clinical responses at baseline and at weeks 0, 1, 2, 4, 8, and 12. Inflammatory cytokines (tumour necrosis factor [TNF]-α, transforming growth factor [TGF]-β1, interleukin [IL]-6, IL-8 and IL-1β) and BDNF levels were also measured. Mixed models repeated measurement was used to examine the therapeutic effect and changes in BDNF and cytokine levels between the groups. HDRS and YMRS scores significantly (P < 0.001) declined in both groups, the SBP group had significantly lower levels of BDNF (P = 0.005) and TGF-β1 (P = 0.02). Patients with SBP and BP-II respond similarly to treatment, but SBP patients may have different neuroinflammation marker expression.
Relation:	Scientific Reports
Appears in Collections:	[Department of Psychology] Journal Article

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