Postoperative Survival Analysis and Its Affecting Factors Investigation of the Oral Cancer

ASIA unversity > 醫學暨健康學院 > 健康產業管理學系 > 健康管理組 > 博碩士論文 > Item 310904400/10787

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題名:	Postoperative Survival Analysis and Its Affecting Factors Investigation of the Oral Cancer
作者:	Pi-Yu Shih
貢獻者:	Department of Healthcare Administration/Healthcare Division
關鍵詞:	Oral cancer, surgical risk factors, core indicators
日期:	2010
上傳時間:	2010-11-05 08:31:18 (UTC+0)
出版者:	Asia University
摘要:	Background: Oral cancer is one of the top 10 cancer that causes death in Taiwan. According to 2007 Form Bureau of Health Promotion, the incidence and mortality of oral cancer remained at the fourth in males since 1997. In addition, the incidence of oral cancer has shown the most significant increased among all cancers between 1998 and 2007. Purpose: The aim of this study is correlate the collected core indicators from surgery of oral cancer to the survival analysis and to provide advices to the national health agencies or other researches. Methods: All data of this study were obtained from the Cancer Registry of a Medical center in the central Taiwan. The parameter is include gender, age, oral habits (tobacco, alcohol, betel nut), tumor size, location, cervical lymph node metastases, pathological stage, histological grade, date of treatment, last contact date and vital status. Results: In this study, 239 patients were male (90.5%) and 25 were female (9.5%); the male-to-female ratio was 9.56: 1. The mean age at diagnosis was lower in male, which was 49.87±10.4 year old, while the mean age of female was 56 ± 13.7 year old. Tongue and buccal mucosa were the most common locations of involvement. The most common histological type was squamous cell carcinoma(98.9％). With Kaplan-Meier Analysis, the overall survival rate was 57.046 ± 1.751 months. According to Cox regression and Log-Rank Test, we found the most important factors correlated to survival were：perineural invasion, positive lymph node and neck dissection including more than 10 lymph nodes and tumor size. Conclusion: Although surgery is the gold standard for oral cancer treatment, there has been no clear standard in surgical practice in our country. Our study presented the surgery-related core indicators which have significant influence in survival rate. We hope that our data may provide the national health authorities to set up a surgical guideline of oral cancer treatment in order to improve the quality of treatment and the survival rate.
顯示於類別:	[健康管理組] 博碩士論文

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