| Abstract: | Background:
Oral cancer is one of the top 10 cancer that causes death in Taiwan.
According to 2007 Form Bureau of Health Promotion, the incidence and
mortality of oral cancer remained at the fourth in males since 1997. In
addition, the incidence of oral cancer has shown the most significant
increased among all cancers between 1998 and 2007.
Purpose:
The aim of this study is correlate the collected core indicators from
surgery of oral cancer to the survival analysis and to provide advices to
the national health agencies or other researches.
Methods:
All data of this study were obtained from the Cancer Registry of a
Medical center in the central Taiwan. The parameter is include gender,
age, oral habits (tobacco, alcohol, betel nut), tumor size, location, cervical
lymph node metastases, pathological stage, histological grade, date of
treatment, last contact date and vital status.
Results:
In this study, 239 patients were male (90.5%) and 25 were female
(9.5%); the male-to-female ratio was 9.56: 1. The mean age at diagnosis
was lower in male, which was 49.87±10.4 year old, while the mean age
of female was 56 ± 13.7 year old. Tongue and buccal mucosa were the
most common locations of involvement. The most common histological
type was squamous cell carcinoma(98.9％). With Kaplan-Meier
Analysis, the overall survival rate was 57.046 ± 1.751 months. According
to Cox regression and Log-Rank Test, we found the most important
factors correlated to survival were：perineural invasion, positive lymph
node and neck dissection including more than 10 lymph nodes and tumor
size.
Conclusion:
Although surgery is the gold standard for oral cancer treatment, there
has been no clear standard in surgical practice in our country. Our study
presented the surgery-related core indicators which have significant
influence in survival rate. We hope that our data may provide the national
health authorities to set up a surgical guideline of oral cancer treatment in
order to improve the quality of treatment and the survival rate. |
