The purpose of this study is to analyze the relationship between emergency medical care and the potential drug interactions of the Statins lipid-lowering drugs user. Subjects were selected from the year 2007 National Health Insurance reimbursement database of Taiwan. The characteristics of emergency medical care and potential drug interaction were studied. The study found that 52.6% of the target population were male, age between 17.0 and 89.0, and the average age was 69.5. The main reason for emergency was circulatory system diseases (24.6%). 27.2% of the emergency cases happened in the fall. Statins accounted for 58.7% annually lipid-lowering drugs used; and atorvastatin was the most prescribed statins (67.5%). After analyzing subjects’prescription, this research found potential drug interactions prescribing patterns for the case were atorvastatin/ digoxin, atorvastatin/ fenofibrate, atorvastatin/ gemfibrozil, pravastatin/ fenofibrate, pravastatin/ gemfibrozil and lovastatin/ fenofibrate. In addition to ask medical history of emergency patiens, physicians should check previous medicine usage carefully to avoid potential drug interactions.