The most frequent clinical complication is diabetics. Diabetics are characterized by elevated blood glucose levels resulting sensory nerve damage or lesions. The wounds of diabetic foot are often slow to heal require medical attention and monitoring. The purpose of this study is to evaluate the effect of intervention of infrared radiation therapy on the microcirculation of the lower extremity of diabetic foot. Ten diabetics and 4 non-diabetics were recruited in this study. Diabetics group were conducted in before and after the intervention in each month for three consecutive months; four non-diabetics group was also measured before and after the intervention, each two weeks for one month. Diabetes group: In the first month of experiment, the surface temperature of the foot was significantly improved, and there was no significant change in blood flow before and after the experiment. The second month of the experiment, the foot surface temperature did not significantly improve, but the foot of the internal blood circulation has improved significantly. In the third month of the experiment, the surface temperature of the foot was significantly decreased and the blood flow was also significantly decreased. Non-diabetics: In the first time of experiment, the surface temperature of the foot was improved but no significant change was made. There was no significant change in blood flow before and after the experiment. The second time of the experiment, the foot surface temperature did not significantly improve, but the foot of the internal blood circulation has improved significantly. In the third time of experiment, the surface temperature of the foot was significantly improved, and there was no significant difference in blood flow. The results of this study, not only on the clinical evaluation of infrared, but also can be applied to clinical products.