AC-10 Inhibits EMT Via The Modulation of Wnt/β-catenin and Inhibition of Smad2 Signaling Pathways in Triple-Negative Breast Cancer Cells

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Title:	AC-10 Inhibits EMT Via The Modulation of Wnt/β-catenin and Inhibition of Smad2 Signaling Pathways in Triple-Negative Breast Cancer Cells
Authors:	Pan, Jian-You
Contributors:	生物科技學系
Keywords:	epithelial-to-mesenchymal transition;MDA-MB-231;TGF-β signaling pathways
Date:	2017
Issue Date:	2017-09-13 05:33:38 (UTC+0)
Publisher:	亞洲大學
Abstract:	AC-10 is a well-known traditional Chinese medicine in Taiwan. AC-10 possesses many bioactivities including anticancer activity. AC-10 showed anti-breast cancer effect induced breast cancer cell apoptosis, however, the metastasis was not clearly studied. TGF-β is a pleiotropic, anti-inflammatory cytokine and a pivotal regulator of a wide range of cellular processes, including cell cycle, proliferation, differentiation, epithelial-to-mesenchymal transition (EMT) and metastasis. In cancer cells, EMT confers tumor cells with a distinct advantage for metastatic dissemination. In this study, MDA-MB-231 cells were treated with AC-10 (0-60 μg/mL) for 24 h. The protein levels of E-cadherin in whole cells were determined by Western blotting. AC-10 up-regulates E-cadherin expression. Results showed that AC-10 inhibited EMT via modulation of Wnt/β-catenin and inhibition of Smad2/3 signaling pathways on triple-negative breast cancer (MDA-MB-231) cells in vitro and in vivo.
Appears in Collections:	[Department of Biotechnology] Theses & dissertations

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