Since nurse services have to consider patient’s thoughts and feelings, so nurses often play multiple roles. Because of that, it creates role conflict and ambiguity. We call that “Cynicism”, it will cause negative impact for organization. If we can prevent it, it will decrease the negative impact and increase effective management. In this paper we aim to explain the relationship of nurse cynicism between workplace deviance behavior and turnover intention. And humorous style regulate whether the relationship between it or not. This study use questionnaires and convenience sampling method to collect information from nurses and practitioners that total are 359 subjects in Taiwan. We use hierarchical regression analysis to test research hypotheses in this research. The results are as follows. First, this has a positive correlation between workplace deviance behavior and turnover intention in employee cynicism. Second, this has a major effect in aggressive humor for overall workplace deviance behavior. Third, this has a major effect in aggressive humor for interpersonal deviance behavior. Fourth, this has a major effect in self-enhancing humor for turnover intention. Finally, four types of humorous style have no effect of adjustment in employee cynicism between relationship of workplace deviance behavior and turnover intention.