Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/102081

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Title:	Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol
Authors:	Huang, M.-H.;Huang, Ming-Hsien;沈育芳;Shen, Yu-Fang;Hsu, Tuan-Ti;Hsu, Tuan-Ti;Tsui-Hsien, Hsien H;Huang, Tsui-Hsien;*
Contributors:	生物資訊與醫學工程學系
Date:	2016-08
Issue Date:	2017-03-01 05:49:02 (UTC+0)
Abstract:	Hinokitiol is a natural material and it has antibacterial and anti-inflammatory effects. The purpose of this study was to evaluate the material characterization, cell viability, antibacterial and anti-inflammatory abilities of the hinokitiol-modified calcium silicate (CS) cement as a root end filling material. The setting times, diametral tensile strength (DTS) values and XRD patterns of CS cements with 0–10 mM hinokitiol were examined. Then, the antibacterial effect and the expression levels of cyclooxygenase 2 (COX-2) and interleukin-1 (IL-1) of the hinokitiol-modified CS cements were evaluated. Furthermore, the cytocompatibility, the expression levels of the markers of odontoblastic differentiation, mineralized nodule formation and calcium deposition of human dental pulp cells (hDPCs) cultured on hinokitiol-modified CS cements were determined. The hinokitiol-modified CS cements had better antibacterial and anti-inflammatory abilities and cytocompatibility than non-modified CS cements. Otherwise, the hinokitiol-modified CS cements had suitable setting times and better odontoblastic potential of hDPCs. Previous report pointed out that the root-end filling materials may induce inflammatory cytokines reaction. In our study, hinokitiol-modified CS cements not only inhibited the expression level of inflammatory cytokines, but also had better cytocompatibility, antimicrobial properties and active ability of odontoblastic differentiation of hDPCs. Therefore, the hinokitiol-modified CS cement may be a potential root end filling material for clinic.
Relation:	Materials Science & Engineering C-Materials for Biological Applications
Appears in Collections:	[Department of Biomedical informatics ] Journal Article

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