The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism

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Title:	The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism
Authors:	李聖玉;Lee, Sheng-Yu;王姿云;Wang, Tzu-Yun;陳秀蘭;Chen, Shiou-Lan;張芸瑄;Chang, Yun-Hsuan;陳柏熹;Chen, Po See;黃三原;Huang, San-Yuan;曾念生;Tzeng, Nian-Sheng;王亮人;Wang, Liang-Jan;李怡慧;I Hui Lee;陳高欽;Kao Chin Chen;楊延光;Yang, Yen Kuang;Yang, Yi-Hsin;Yang, Yi-Hsin;陸汝斌;Lu, Ru-Band;*;Cheng-Sheng;Chen, Cheng-Sheng
Contributors:	心理學系
Date:	2016-12
Issue Date:	2017-03-01 05:40:13 (UTC+0)
Abstract:	We explored the effect of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) on correlation between changes in plasma BDNF levels with cognitive function and quality of life (QoL) after 12 weeks of treatment in bipolar disorder (BD). Symptom severity and plasma BDNF levels were assessed upon recruitment and during weeks 1, 2, 4, 8 and 12. QoL, the Wisconsin Card Sorting Test (WCST), and the Conners’ Continuous Performance Test (CPT) were assessed at baseline and endpoint. The BDNF Val66Met polymorphism was genotyped. Changes in cognitive function and QoL over 12 weeks were reduced using factor analysis for the evaluation of their correlations with changes in plasma BDNF. Five hundred forty-one BD patients were recruited and 65.6% of them completed the 12-week follow-up. Changes in plasma BDNF levels with factor 1 (WCST) were significantly negatively correlated (r = −0.25, p = 0.00037). After stratification of BD subtypes and BDNF genotypes, this correlation was significant only in BP-I and the Val/Met genotype (r = −0.54, p = 0.008). We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD.
Relation:	Scientific Reports
Appears in Collections:	[心理學系] 期刊論文

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