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| Title: | Phytochemicals from Tradescantia albiflora Kunth extracts reduce serum uric acid levels in oxonate-induced mice |
| Authors: | Wan, Wen-Ling;Wang, Wen-Ling;She, Shi-Yuan;Sheu, Shi-Yuan;Huan, Wen-Dar;Huang, Wen-Dar;Chua, Ya-Ling;Chuang, Ya-Ling;Tse, Han-Chun;Tseng, Han-Chun;Tzann-Shun, H;Hwang, Tzann-Shun;Yuan-Tsung, F;Fu, Yuan-Tsung;Yueh-Hsiung;Kuo, Yueh-Hsiung;姚俊旭;Yao*, Chun-Hsu;Kuo, Tzong-Fu;Kuo, Tzong-Fu |
| Contributors: | 生物資訊與醫學工程學系 |
| Date: | 2016-08 |
| Issue Date: | 2016-12-05 06:17:51 (UTC+0) |
| Abstract: | Background:
Tradescantia albiflora (TA) Kunth (Commelinaceae) has
been used for treating gout and hyperuricemia as folklore remedies in
Taiwan. Therefore, it is worthwhile to study the effect of TA extracts on
lowering uric acid activity. The hypouricemic effects of TA extracts on
potassium oxonate (PO)‑induced acute hyperuricemia were investigated
for the first time.
Materials and Methods:
All treatments at the same
volume (1 ml) were orally administered to the abdominal cavity of
PO‑induced hyperuricemic rats. One milliliter of TA extract in n-hexane
(HE), ethyl acetate (EA), n-butanol (BuOH), and water fractions has 0.28,
0.21, 0.28, and 1.03 mg TA, respectively; and the plasma uric acid (PUA)
level was measured for a consecutive 4 h after administration.
Results:
All four fractions’ extracts derived from TA were observed to significantly
reduce PUA compared with the PO group. The EA‑soluble fraction (TA‑EA)
exhibited the best xanthine oxidase (XO) inhibitory activity. Following
column chromatography, 12 phytochemicals were isolated and identified
from the EA fraction. The IC50 values of isolated phytochemicals indicated
that bracteanolide A (AR11) showed the remarkable XO inhibitory
effect (IC50 value of 76.4 µg/ml). These findings showed that the in vivo
hypouricemic effect in hyperuricemic rats was consistent with in vitro XO
inhibitory activity, indicating that TA extracts and derived phytochemicals
could be potential candidates as hypouricemic agents. |
| Relation: | Pharmacognosy Magazine |
| Appears in Collections: | [生物資訊與醫學工程學系 ] 期刊論文
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