The differential levels of inflammatory cytokines and BDNF among bipolar spectrum disorders

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Title:	The differential levels of inflammatory cytokines and BDNF among bipolar spectrum disorders
Authors:	王姿云;Wang, Tzu-Yun;李聖玉;Lee, Sheng-Yu;陳秀蘭;Chen, Shiou-Lan;鍾宜倫;Chung, Yi-Lun;李佳玲;Li, Chia-Ling;張芸瑄;Chang, Yun-Hsuan;王亮人;Wang, Liang-Jen;陳柏熹;Chen, Po See;陳世恆;Shih-Heng Chen;朱俊憲;Chun-Hsien Chu;黃三原;Huang, San-Yuan;曾念生;Tzeng, Nian-Sheng;謝采芯;Hsieh, Tsai-Hsin;Chiu, Yen-Chu;Chiu, Yen-Chu
Contributors:	心理學系
Date:	2016-02
Issue Date:	2016-08-08 06:27:07 (UTC+0)
Abstract:	Objective: Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines and brain-derived neurotrophic factor between bipolar I, bipolar II, and other specified bipolar disorder with short duration hypomania may support the association with inflammatory dysregulation and bipolar disorder and, more specifically, provide evidence for other specified bipolar disorder with short duration hypomania patients were similar to bipolar II disorder patients from a biological marker perspective. Methods: We enrolled patients with bipolar I disorder (n=234), bipolar II disorder (n=260), other specified bipolar disorder with short duration hypomania (n=243), and healthy controls (n=140). Their clinical symptoms were rated using the Hamilton Depression Rating Scale and Young Mania Rating Scale. Inflammatory cytokine (tumor necrosis factor-α, C-reactive protein, transforming growth factor-β1, and interleukin-8) and brain-derived neurotrophic factor levels were measured in each group. Multivariate analysis of covariance and linear regression controlled for possible confounders were used to compare cytokine and brain-derived neurotrophic factor levels among the groups. Results: Multivariate analysis of covariance adjusted for age and sex and a main effect of diagnosis was significant (P<.001). Three of the 5 measured biomarkers (tumor necrosis factor-α, transforming growth factor-β1, and interleukin-8) were significantly (P=.006, .01, and <.001) higher in all bipolar disorder patients than in controls. Moreover, covarying for multiple associated confounders showed that bipolar I disorder patients had significantly higher IL-8 levels than did bipolar II disorder and other specified bipolar disorder with short duration hypomania patients in multivariate analysis of covariance (P=.03) and linear regression (P=.02) analyses. Biomarkers differences between bipolar II disorder and other specified bipolar disorder with short duration hypomania patients were nonsignificant. Conclusion: The immunological disturbance along the bipolar spectrum was most severe in bipolar I disorder patients. Other specified bipolar disorder with short duration hypomania patients and bipolar II disorder patients did not differ in these biological markers.
Relation:	INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Appears in Collections:	[Department of Psychology] Journal Article

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